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Mitochondrial dysfunction in pathophysiology of heart failure
Bo Zhou and Rong Tian
Mitochondria and Metabolism Center, U. of Washington, Seattle, Washington, USA.
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J Clin Invest. 2018;128(9):3716-3726.
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Conclusion :
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Heart failure is a complex clinical syndrome that represents the final outcome of failed compensation for cardiac injury caused by a variety of etiologies.
Mitochondrial dysfunction develops as the result of unsuccessful adaptation to energy stress in the heart, which, in turn, perpetuates a maladaptive spiral to further cardiac damage. As summarized here, a number of mitochondria-mediated mechanisms have been identified that drive the demise of the heart prior to the ultimate ATP depletion. These observations will not only provide important links between cardiac stress and energy starvation during the development of heart failure but will also inspire therapeutic approaches for mitochondrial dysfunction.
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